Drug interactions
Maraviroc + Red yeast rice
Severity: Minor
Maraviroc and Red yeast rice: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monacolin K (lovastatin) and maraviroc are both CYP3A4 substrates, and maraviroc is also a P-glycoprotein substrate. An effect on maraviroc exposure is only theoretical, and no clear clinically significant interaction is established.
What this interaction means in plain words
Maraviroc and Red yeast rice have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maraviroc belongs to Anti Virals; Red yeast rice belongs to Gastrointestinal Tract.
Why it happens
Possible weak P-glycoprotein or CYP3A4 competition by monacolin K; the mechanism is not firmly established.
What to do
No dose change is usually needed. Monitor for maraviroc adverse effects such as dizziness or hypotension, and for muscle symptoms from the statin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Red yeast rice
- Red yeast rice + Ritonavir Contraindicated
- Red yeast rice + Saquinavir Contraindicated
- Red yeast rice + Tipranavir Contraindicated
- Atazanavir + Red yeast rice Major
- Atorvastatin + Red yeast rice Major
- Conivaptan + Red yeast rice Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Red yeast rice?
MediHelp rates the interaction as minor. Maraviroc and Red yeast rice have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Monacolin K (lovastatin) and maraviroc are both CYP3A4 substrates, and maraviroc is also a P-glycoprotein substrate. An effect on maraviroc exposure is only theoretical, and no clear clinically significant interaction is established.
How serious is the interaction between Maraviroc and Red yeast rice?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for maraviroc adverse effects such as dizziness or hypotension, and for muscle symptoms from the statin.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
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