Drug interactions
Marijuana + Posaconazole
Severity: Minor
Marijuana and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase concentrations of THC and CBD, intensifying sedation, dizziness, tachycardia and impaired cognition. Effects depend on route and product, and data are limited.
What this interaction means in plain words
Marijuana and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Posaconazole inhibits CYP3A4, which contributes to cannabinoid metabolism.
What to do
Advise patients to use lower cannabis doses and watch for excess sedation or tachycardia. Avoid driving until effects are known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Marijuana with Posaconazole?
MediHelp rates the interaction as minor. Marijuana and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may increase concentrations of THC and CBD, intensifying sedation, dizziness, tachycardia and impaired cognition. Effects depend on route and product, and data are limited.
How serious is the interaction between Marijuana and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to use lower cannabis doses and watch for excess sedation or tachycardia. Avoid driving until effects are known.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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