Drug interactions
Mavacamten + Ranolazine
Severity: Moderate
Mavacamten and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility and ranolazine has modest negative inotropic effects, so heart failure from systolic dysfunction is a concern. The combination is not well studied.
What this interaction means in plain words
Mavacamten and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic reduction of myocardial contractility; ranolazine also weakly inhibits CYP3A4 and P-gp.
What to do
Monitor left ventricular ejection fraction and clinical signs of heart failure per mavacamten monitoring schedule. Reduce or stop mavacamten if ejection fraction falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Ranolazine?
MediHelp rates the interaction as moderate. Mavacamten and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten reduces cardiac contractility and ranolazine has modest negative inotropic effects, so heart failure from systolic dysfunction is a concern. The combination is not well studied.
How serious is the interaction between Mavacamten and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical signs of heart failure per mavacamten monitoring schedule. Reduce or stop mavacamten if ejection fraction falls.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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