Drug interactions
Mavacamten + Sotalol
Severity: Moderate
Mavacamten and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility, and beta-blockers such as sotalol also have negative inotropic and chronotropic effects. Together they may worsen reduced ejection fraction and heart failure, although beta-blockers are often used in obstructive hypertrophic cardiomyopathy.
What this interaction means in plain words
Mavacamten and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects through myosin inhibition and beta-adrenergic blockade.
What to do
Monitor left ventricular ejection fraction by echocardiography and clinical heart failure signs, with mavacamten dose adjusted per label. Interrupt mavacamten if ejection fraction falls markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Sotalol?
MediHelp rates the interaction as moderate. Mavacamten and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten reduces cardiac contractility, and beta-blockers such as sotalol also have negative inotropic and chronotropic effects. Together they may worsen reduced ejection fraction and heart failure, although beta-blockers are often used in obstructive hypertrophic cardiomyopathy.
How serious is the interaction between Mavacamten and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction by echocardiography and clinical heart failure signs, with mavacamten dose adjusted per label. Interrupt mavacamten if ejection fraction falls markedly.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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