Drug interactions
Measles mumps and rubella vaccine + Ozanimod
Severity: Major
Measles mumps and rubella vaccine and Ozanimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod reduces circulating lymphocytes, which may weaken vaccine responses and raise the risk of vaccine-strain infection with live vaccines. Live vaccines should be avoided during treatment and for a period afterward.
What this interaction means in plain words
Measles mumps and rubella vaccine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Measles mumps and rubella vaccine belongs to Miscellaneous; Ozanimod belongs to Central Nervous System.
Why it happens
S1P receptor modulation sequesters lymphocytes in lymphoid tissue, reducing circulating lymphocytes and immune control of live attenuated virus.
What to do
Avoid MMR during ozanimod and for up to 3 months after stopping; vaccinate at least 4 weeks before starting where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Ozanimod?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod reduces circulating lymphocytes, which may weaken vaccine responses and raise the risk of vaccine-strain infection with live vaccines. Live vaccines should be avoided during treatment and for a period afterward.
How serious is the interaction between Measles mumps and rubella vaccine and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid MMR during ozanimod and for up to 3 months after stopping; vaccinate at least 4 weeks before starting where possible.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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