Drug interactions
Measles mumps and rubella vaccine + Temsirolimus
Severity: Major
Measles mumps and rubella vaccine and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus is an mTOR inhibitor with immunosuppressive effects. It may blunt the response to vaccination, and live vaccine viruses may replicate to cause vaccine-strain disease.
What this interaction means in plain words
Measles mumps and rubella vaccine and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Measles mumps and rubella vaccine belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
mTOR inhibition suppresses lymphocyte proliferation, impairing control of live attenuated virus.
What to do
Avoid MMR during temsirolimus treatment. Vaccinate beforehand where possible, or defer until immune recovery after stopping.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Temsirolimus?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temsirolimus is an mTOR inhibitor with immunosuppressive effects. It may blunt the response to vaccination, and live vaccine viruses may replicate to cause vaccine-strain disease.
How serious is the interaction between Measles mumps and rubella vaccine and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid MMR during temsirolimus treatment. Vaccinate beforehand where possible, or defer until immune recovery after stopping.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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