Drug interactions
Mecasermin + Miglitol
Severity: Moderate
Mecasermin and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin has insulin-like glucose-lowering action and can cause hypoglycemia. Miglitol alone rarely causes hypoglycemia, but it slows carbohydrate absorption so oral sucrose may be ineffective as rescue.
What this interaction means in plain words
Mecasermin and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mecasermin belongs to Endocrine; Miglitol belongs to Endocrine.
Why it happens
Additive glucose lowering from IGF-1 receptor activation plus delayed carbohydrate absorption.
What to do
Monitor blood glucose and give mecasermin with food. Treat hypoglycemia with glucose rather than sucrose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mecasermin
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Mecasermin with Miglitol?
MediHelp rates the interaction as moderate. Mecasermin and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin has insulin-like glucose-lowering action and can cause hypoglycemia. Miglitol alone rarely causes hypoglycemia, but it slows carbohydrate absorption so oral sucrose may be ineffective as rescue.
How serious is the interaction between Mecasermin and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and give mecasermin with food. Treat hypoglycemia with glucose rather than sucrose.
What other medicines interact with Mecasermin?
MediHelp also lists interactions of Mecasermin with, for example, Gliclazide, Glyburide-metformin, Insulin degludec-insulin aspart. The full list is on the Mecasermin page.
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