Drug interactions
Mechlorethamine + Ocrelizumab
Severity: Moderate
Mechlorethamine and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is a cytotoxic alkylating agent, but the topical gel form has minimal systemic absorption. The interaction with ocrelizumab is only theoretical and depends on the route used.
What this interaction means in plain words
Mechlorethamine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mechlorethamine belongs to Oncology; Ocrelizumab belongs to Central Nervous System.
Why it happens
Potential additive immunosuppression and myelosuppression if systemic mechlorethamine is used with anti-CD20 B-cell depletion.
What to do
If systemic mechlorethamine is given, monitor blood counts and watch for infection. Topical use needs no change beyond routine skin infection awareness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Mechlorethamine with Ocrelizumab?
MediHelp rates the interaction as moderate. Mechlorethamine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mechlorethamine is a cytotoxic alkylating agent, but the topical gel form has minimal systemic absorption. The interaction with ocrelizumab is only theoretical and depends on the route used.
How serious is the interaction between Mechlorethamine and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic mechlorethamine is given, monitor blood counts and watch for infection. Topical use needs no change beyond routine skin infection awareness.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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