Drug interactions
Mechlorethamine + Vedolizumab
Severity: Moderate
Mechlorethamine and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is a myelosuppressive alkylating agent, and vedolizumab alters gut immune trafficking. Together they may modestly raise infection risk, although vedolizumab is gut-selective and has limited systemic immunosuppression.
What this interaction means in plain words
Mechlorethamine and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mechlorethamine belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive effects: chemotherapy-related myelosuppression plus integrin-mediated gut-selective immunosuppression.
What to do
Monitor blood counts and for infection, particularly gastrointestinal infection. Adjust chemotherapy for cytopenias per standard practice.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Mechlorethamine with Vedolizumab?
MediHelp rates the interaction as moderate. Mechlorethamine and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mechlorethamine is a myelosuppressive alkylating agent, and vedolizumab alters gut immune trafficking. Together they may modestly raise infection risk, although vedolizumab is gut-selective and has limited systemic immunosuppression.
How serious is the interaction between Mechlorethamine and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infection, particularly gastrointestinal infection. Adjust chemotherapy for cytopenias per standard practice.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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