Drug interactions
Meclizine + Metoclopramide
Severity: Moderate
Meclizine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is a sedating antihistamine with anticholinergic properties. With metoclopramide, additive drowsiness and impaired psychomotor performance can occur, and the anticholinergic effect may oppose metoclopramide's gastric motility enhancement.
What this interaction means in plain words
Meclizine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and pharmacodynamic antagonism between anticholinergic activity and cholinergic prokinetic action.
What to do
Counsel patients about sedation and avoid driving until the response is known. Reassess the need for both agents if nausea control or gastric emptying is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Metoclopramide?
MediHelp rates the interaction as moderate. Meclizine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is a sedating antihistamine with anticholinergic properties. With metoclopramide, additive drowsiness and impaired psychomotor performance can occur, and the anticholinergic effect may oppose metoclopramide's gastric motility enhancement.
How serious is the interaction between Meclizine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation and avoid driving until the response is known. Reassess the need for both agents if nausea control or gastric emptying is inadequate.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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