Drug interactions
Meclizine + Prochlorperazine
Severity: Moderate
Meclizine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both have antihistaminic and anticholinergic properties, so together they can cause additive drowsiness, dry mouth, blurred vision, constipation and urinary retention. They are also commonly redundant antiemetic or antivertigo therapy.
What this interaction means in plain words
Meclizine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive anticholinergic and antihistaminic (H1) effects with additive CNS depression.
What to do
Avoid using both for the same indication where possible, and monitor for anticholinergic effects and sedation, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meclizine and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Prochlorperazine?
MediHelp rates the interaction as moderate. Meclizine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both have antihistaminic and anticholinergic properties, so together they can cause additive drowsiness, dry mouth, blurred vision, constipation and urinary retention. They are also commonly redundant antiemetic or antivertigo therapy.
How serious is the interaction between Meclizine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both for the same indication where possible, and monitor for anticholinergic effects and sedation, especially in older adults.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
