Drug interactions
Meclofenamic acid + Methylprednisolone
Severity: Moderate
Meclofenamic acid and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of an NSAID and a systemic corticosteroid markedly increases the risk of peptic ulceration and gastrointestinal bleeding.
What this interaction means in plain words
Meclofenamic acid and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Methylprednisolone belongs to Endocrine.
Why it happens
NSAIDs impair gastric mucosal protection through prostaglandin inhibition while corticosteroids impair mucosal healing, giving additive ulcer risk.
What to do
Use the shortest duration possible and consider a proton pump inhibitor for gastroprotection. Counsel patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Meclofenamic acid with Methylprednisolone?
MediHelp rates the interaction as moderate. Meclofenamic acid and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of an NSAID and a systemic corticosteroid markedly increases the risk of peptic ulceration and gastrointestinal bleeding.
How serious is the interaction between Meclofenamic acid and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest duration possible and consider a proton pump inhibitor for gastroprotection. Counsel patients to report black stools or abdominal pain.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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