Drug interactions
Meclofenamic acid + Metolazone
Severity: Moderate
Meclofenamic acid and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effect of thiazide-like diuretics such as metolazone. Concurrent use may also raise the risk of renal impairment in volume-depleted patients.
What this interaction means in plain words
Meclofenamic acid and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Metolazone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal blood flow, opposing diuretic action.
What to do
Monitor blood pressure, weight or edema, and renal function, and maintain hydration. Adjust the diuretic dose or choose a non-NSAID analgesic if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Metolazone
Frequently asked questions
Can I take Meclofenamic acid with Metolazone?
MediHelp rates the interaction as moderate. Meclofenamic acid and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effect of thiazide-like diuretics such as metolazone. Concurrent use may also raise the risk of renal impairment in volume-depleted patients.
How serious is the interaction between Meclofenamic acid and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight or edema, and renal function, and maintain hydration. Adjust the diuretic dose or choose a non-NSAID analgesic if response is lost.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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