Drug interactions
Meclofenamic acid + Paromomycin
Severity: Minor
Meclofenamic acid and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic NSAIDs can lower aminoglycoside clearance, an effect described mostly in neonates. Oral paromomycin is minimally absorbed, so the interaction is unlikely to matter unless absorption increases through intestinal damage or renal failure.
What this interaction means in plain words
Meclofenamic acid and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meclofenamic acid belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced decrease in glomerular filtration can reduce clearance of any absorbed aminoglycoside.
What to do
No action is generally needed. In renal impairment or severe bowel disease, monitor renal function and watch for oto- or nephrotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Meclofenamic acid with Paromomycin?
MediHelp rates the interaction as minor. Meclofenamic acid and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic NSAIDs can lower aminoglycoside clearance, an effect described mostly in neonates. Oral paromomycin is minimally absorbed, so the interaction is unlikely to matter unless absorption increases through intestinal damage or renal failure.
How serious is the interaction between Meclofenamic acid and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. In renal impairment or severe bowel disease, monitor renal function and watch for oto- or nephrotoxicity.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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