Drug interactions
Meclofenamic acid + Vadadustat
Severity: Moderate
Meclofenamic acid and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is a substrate of renal OAT3, and inhibitors of this transporter may raise its exposure. Meclofenamic acid could therefore increase vadadustat levels, causing an excessive or rapid hemoglobin rise and associated thrombotic or hypertensive risk.
What this interaction means in plain words
Meclofenamic acid and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Why it happens
Possible inhibition of OAT1/OAT3-mediated transport of vadadustat, raising its exposure.
What to do
Monitor hemoglobin regularly and reduce or hold vadadustat if the rise is too rapid or excessive. Check blood pressure and watch for adverse reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Meclofenamic acid with Vadadustat?
MediHelp rates the interaction as moderate. Meclofenamic acid and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat is a substrate of renal OAT3, and inhibitors of this transporter may raise its exposure. Meclofenamic acid could therefore increase vadadustat levels, causing an excessive or rapid hemoglobin rise and associated thrombotic or hypertensive risk.
How serious is the interaction between Meclofenamic acid and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly and reduce or hold vadadustat if the rise is too rapid or excessive. Check blood pressure and watch for adverse reactions.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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