Drug interactions
Meclofenamic acid + Vortioxetine
Severity: Moderate
Meclofenamic acid and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine is a serotonergic antidepressant that can impair platelet function, and with NSAIDs this increases bleeding risk, particularly gastrointestinal.
What this interaction means in plain words
Meclofenamic acid and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake impairs aggregation, additive to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for bleeding signs and consider gastroprotection in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Meclofenamic acid with Vortioxetine?
MediHelp rates the interaction as moderate. Meclofenamic acid and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine is a serotonergic antidepressant that can impair platelet function, and with NSAIDs this increases bleeding risk, particularly gastrointestinal.
How serious is the interaction between Meclofenamic acid and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and consider gastroprotection in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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