Drug interactions
Medroxyprogesterone + Metformin
Severity: Minor
Medroxyprogesterone and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Medroxyprogesterone, especially as depot injections, can impair glucose tolerance and increase insulin resistance. This may reduce the effectiveness of metformin and slightly worsen glycemic control.
What this interaction means in plain words
Medroxyprogesterone and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through progestin-related reduction in insulin sensitivity.
What to do
Monitor glucose and HbA1c after starting medroxyprogesterone and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Metformin?
MediHelp rates the interaction as minor. Medroxyprogesterone and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Medroxyprogesterone, especially as depot injections, can impair glucose tolerance and increase insulin resistance. This may reduce the effectiveness of metformin and slightly worsen glycemic control.
How serious is the interaction between Medroxyprogesterone and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting medroxyprogesterone and adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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