Drug interactions
Medroxyprogesterone + Nafcillin
Severity: Moderate
Medroxyprogesterone and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin appears to induce CYP3A4 and may lower exposure to hormonal steroids such as medroxyprogesterone. Reduced contraceptive efficacy is possible during and shortly after nafcillin therapy.
What this interaction means in plain words
Medroxyprogesterone and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by nafcillin, increasing progestin clearance.
What to do
Advise a backup barrier contraceptive method during nafcillin therapy and for a short period after it ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Nafcillin?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin appears to induce CYP3A4 and may lower exposure to hormonal steroids such as medroxyprogesterone. Reduced contraceptive efficacy is possible during and shortly after nafcillin therapy.
How serious is the interaction between Medroxyprogesterone and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise a backup barrier contraceptive method during nafcillin therapy and for a short period after it ends.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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