Drug interactions
Medroxyprogesterone + Nefazodone
Severity: Moderate
Medroxyprogesterone and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may raise medroxyprogesterone concentrations. Progestogenic adverse effects might become more pronounced.
What this interaction means in plain words
Medroxyprogesterone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of medroxyprogesterone by nefazodone.
What to do
Monitor for progestogenic adverse effects such as bleeding changes, fluid retention and mood effects. Reassess the hormonal regimen if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Nefazodone?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may raise medroxyprogesterone concentrations. Progestogenic adverse effects might become more pronounced.
How serious is the interaction between Medroxyprogesterone and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as bleeding changes, fluid retention and mood effects. Reassess the hormonal regimen if they occur.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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