Drug interactions
Mefenamic acid + Sparsentan
Severity: Major
Mefenamic acid and Sparsentan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan reduces glomerular pressure through endothelin and angiotensin receptor blockade, and NSAIDs can further impair renal hemodynamics. Concurrent use may cause deterioration of kidney function and hyperkalemia.
What this interaction means in plain words
Mefenamic acid and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mefenamic acid belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
NSAID inhibition of vasodilatory prostaglandins combined with efferent arteriolar dilation from angiotensin receptor blockade reduces glomerular filtration.
What to do
Avoid regular NSAID use in patients on sparsentan; use paracetamol for analgesia. If an NSAID is necessary, monitor serum creatinine and potassium closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Mefenamic acid with Sparsentan?
MediHelp rates the interaction as major. Mefenamic acid and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan reduces glomerular pressure through endothelin and angiotensin receptor blockade, and NSAIDs can further impair renal hemodynamics. Concurrent use may cause deterioration of kidney function and hyperkalemia.
How serious is the interaction between Mefenamic acid and Sparsentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use in patients on sparsentan; use paracetamol for analgesia. If an NSAID is necessary, monitor serum creatinine and potassium closely.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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