Drug interactions
Mefenamic acid + Tolazamide
Severity: Moderate
Mefenamic acid and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate sulfonylurea effects and occasionally cause hypoglycemia. The risk is modest but relevant in older or renally impaired patients.
What this interaction means in plain words
Mefenamic acid and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and reduced renal clearance; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping the NSAID and warn patients about hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Mefenamic acid with Tolazamide?
MediHelp rates the interaction as moderate. Mefenamic acid and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate sulfonylurea effects and occasionally cause hypoglycemia. The risk is modest but relevant in older or renally impaired patients.
How serious is the interaction between Mefenamic acid and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and warn patients about hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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