Drug interactions
Mefloquine + Nadolol
Severity: Minor
Mefloquine and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can slow the heart rate and AV conduction. Combined use may cause additive bradycardia or conduction block.
What this interaction means in plain words
Mefloquine and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mefloquine belongs to Anti Parasitic; Nadolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on cardiac conduction; nadolol is mainly renally eliminated, so a metabolic interaction is unlikely.
What to do
Monitor heart rate and blood pressure when starting mefloquine. Reassess therapy if symptomatic bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Mefloquine with Nadolol?
MediHelp rates the interaction as minor. Mefloquine and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can slow the heart rate and AV conduction. Combined use may cause additive bradycardia or conduction block.
How serious is the interaction between Mefloquine and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting mefloquine. Reassess therapy if symptomatic bradycardia occurs.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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