Drug interactions
Mefloquine + Nicardipine
Severity: Moderate
Mefloquine and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP3A4 and may raise mefloquine concentrations, while both drugs can influence cardiac conduction and cause bradycardia or hypotension. This may increase mefloquine toxicity and the risk of conduction abnormalities.
What this interaction means in plain words
Mefloquine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated mefloquine metabolism combined with additive effects on cardiac conduction.
What to do
Monitor heart rate, blood pressure and ECG, and watch for mefloquine neuropsychiatric adverse effects. Consider an alternative antimalarial if bradycardia or conduction disturbance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Mefloquine with Nicardipine?
MediHelp rates the interaction as moderate. Mefloquine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine inhibits CYP3A4 and may raise mefloquine concentrations, while both drugs can influence cardiac conduction and cause bradycardia or hypotension. This may increase mefloquine toxicity and the risk of conduction abnormalities.
How serious is the interaction between Mefloquine and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and watch for mefloquine neuropsychiatric adverse effects. Consider an alternative antimalarial if bradycardia or conduction disturbance develops.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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