Drug interactions
Mefloquine + Oxytocin
Severity: Moderate
Mefloquine and Oxytocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxytocin has been associated with QT prolongation, particularly with rapid intravenous administration, and mefloquine also prolongs QT. Concurrent use may increase the risk of arrhythmia.
What this interaction means in plain words
Mefloquine and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Oxytocin belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Give oxytocin by controlled infusion and monitor the ECG in patients recently taking mefloquine, especially with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mefloquine and Oxytocin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Oxytocin
- Carboprost tromethamine + Oxytocin Major
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
Frequently asked questions
Can I take Mefloquine with Oxytocin?
MediHelp rates the interaction as moderate. Mefloquine and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxytocin has been associated with QT prolongation, particularly with rapid intravenous administration, and mefloquine also prolongs QT. Concurrent use may increase the risk of arrhythmia.
How serious is the interaction between Mefloquine and Oxytocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oxytocin by controlled infusion and monitor the ECG in patients recently taking mefloquine, especially with other QT risk factors.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
