Drug interactions
Mefloquine + Sertraline
Severity: Moderate
Mefloquine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline has a low risk of QT prolongation, while mefloquine can prolong QT and cause neuropsychiatric effects. Combined use may modestly increase arrhythmic risk and overlapping psychiatric adverse effects.
What this interaction means in plain words
Mefloquine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT effects and overlapping neuropsychiatric toxicity.
What to do
Obtain a baseline ECG if other QT risk factors exist and monitor mood and sleep during mefloquine use; consider an alternative antimalarial for patients with unstable psychiatric illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Mefloquine with Sertraline?
MediHelp rates the interaction as moderate. Mefloquine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline has a low risk of QT prolongation, while mefloquine can prolong QT and cause neuropsychiatric effects. Combined use may modestly increase arrhythmic risk and overlapping psychiatric adverse effects.
How serious is the interaction between Mefloquine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG if other QT risk factors exist and monitor mood and sleep during mefloquine use; consider an alternative antimalarial for patients with unstable psychiatric illness.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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