Drug interactions
Mefloquine + Warfarin
Severity: Moderate
Mefloquine and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine has been reported to alter anticoagulant response in some patients, although the data are limited. A change in INR could increase bleeding risk or reduce anticoagulation.
What this interaction means in plain words
Mefloquine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not well established.
What to do
Check INR before starting mefloquine and again within the first week of therapy and after stopping it. Adjust the warfarin dose according to the INR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Mefloquine with Warfarin?
MediHelp rates the interaction as moderate. Mefloquine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine has been reported to alter anticoagulant response in some patients, although the data are limited. A change in INR could increase bleeding risk or reduce anticoagulation.
How serious is the interaction between Mefloquine and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR before starting mefloquine and again within the first week of therapy and after stopping it. Adjust the warfarin dose according to the INR.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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