Drug interactions
Melatonin + Naproxen
Severity: Minor
Melatonin and Naproxen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-documented clinically meaningful interaction exists between melatonin and naproxen. Reports that melatonin may affect coagulation are weak and inconsistent. NSAIDs may reduce endogenous melatonin levels, but the clinical relevance is unclear.
What this interaction means in plain words
Melatonin and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Naproxen belongs to Musculoskeletal.
Why it happens
No established mechanism; effects on coagulation or melatonin secretion are speculative.
What to do
No specific action is required; be aware of the possible effect on sleep or bleeding if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Naproxen?
MediHelp rates the interaction as minor. Melatonin and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-documented clinically meaningful interaction exists between melatonin and naproxen. Reports that melatonin may affect coagulation are weak and inconsistent. NSAIDs may reduce endogenous melatonin levels, but the clinical relevance is unclear.
How serious is the interaction between Melatonin and Naproxen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; be aware of the possible effect on sleep or bleeding if symptoms arise.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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