Drug interactions
Meloxicam + Methylprednisolone
Severity: Moderate
Meloxicam and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with meloxicam increases the risk of gastrointestinal ulceration and bleeding compared with either drug alone. Meloxicam is somewhat more COX-2 selective, but the additive risk remains.
What this interaction means in plain words
Meloxicam and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Methylprednisolone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury: NSAID-related prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest time, and consider a proton pump inhibitor in older or high-risk patients. Monitor for gastrointestinal bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Methylprednisolone?
MediHelp rates the interaction as moderate. Meloxicam and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with meloxicam increases the risk of gastrointestinal ulceration and bleeding compared with either drug alone. Meloxicam is somewhat more COX-2 selective, but the additive risk remains.
How serious is the interaction between Meloxicam and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time, and consider a proton pump inhibitor in older or high-risk patients. Monitor for gastrointestinal bleeding.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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