Drug interactions
Meloxicam + Metolazone
Severity: Moderate
Meloxicam and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam may reduce the diuretic and antihypertensive effect of metolazone and increase the risk of renal impairment, particularly in volume-depleted patients. Metolazone-related electrolyte disturbances may complicate this.
What this interaction means in plain words
Meloxicam and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Metolazone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing diuretic action.
What to do
Monitor blood pressure, weight or edema, renal function and electrolytes. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Metolazone
Frequently asked questions
Can I take Meloxicam with Metolazone?
MediHelp rates the interaction as moderate. Meloxicam and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam may reduce the diuretic and antihypertensive effect of metolazone and increase the risk of renal impairment, particularly in volume-depleted patients. Metolazone-related electrolyte disturbances may complicate this.
How serious is the interaction between Meloxicam and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight or edema, renal function and electrolytes. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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