Drug interactions
Meloxicam + Trazodone
Severity: Moderate
Meloxicam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that can impair platelet aggregation, and combined with an NSAID this increases the risk of bleeding, especially upper gastrointestinal bleeding. The risk is greater in older patients and those with prior ulcers.
What this interaction means in plain words
Meloxicam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake combined with NSAID platelet inhibition and gastric mucosal injury.
What to do
Monitor for signs of gastrointestinal bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Meloxicam with Trazodone?
MediHelp rates the interaction as moderate. Meloxicam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that can impair platelet aggregation, and combined with an NSAID this increases the risk of bleeding, especially upper gastrointestinal bleeding. The risk is greater in older patients and those with prior ulcers.
How serious is the interaction between Meloxicam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose or choose paracetamol.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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