Drug interactions
Meloxicam + Vortioxetine
Severity: Moderate
Meloxicam and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, as a serotonergic antidepressant, can impair platelet aggregation, and combined with an NSAID the risk of bleeding rises, particularly in the gastrointestinal tract.
What this interaction means in plain words
Meloxicam and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake adds to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for bleeding and consider gastroprotection in patients at high risk, such as the elderly or those with ulcer history. Limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Meloxicam with Vortioxetine?
MediHelp rates the interaction as moderate. Meloxicam and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, as a serotonergic antidepressant, can impair platelet aggregation, and combined with an NSAID the risk of bleeding rises, particularly in the gastrointestinal tract.
How serious is the interaction between Meloxicam and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider gastroprotection in patients at high risk, such as the elderly or those with ulcer history. Limit NSAID dose and duration.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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