Drug interactions
Memantine + Saxagliptin-metformin
Severity: Minor
Memantine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is a cationic drug eliminated by renal tubular secretion and may compete with metformin for the same transport. This could modestly raise levels of either drug, though clinically important effects are uncommon.
What this interaction means in plain words
Memantine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transporters (OCT2/MATE) may reduce clearance of metformin and memantine.
What to do
No routine change is needed; watch for metformin or memantine adverse effects, especially in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Memantine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Memantine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is a cationic drug eliminated by renal tubular secretion and may compete with metformin for the same transport. This could modestly raise levels of either drug, though clinically important effects are uncommon.
How serious is the interaction between Memantine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for metformin or memantine adverse effects, especially in patients with reduced renal function.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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