Drug interactions
Memantine + Tafenoquine
Severity: Moderate
Memantine and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits renal OCT2 and MATE transporters in vitro, which may reduce the tubular secretion of memantine. This may raise memantine levels and increase dose-related adverse effects such as dizziness, confusion and agitation.
What this interaction means in plain words
Memantine and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine belongs to Central Nervous System; Tafenoquine belongs to Anti Parasitic.
Why it happens
Inhibition of renal OCT2 and MATE transporters by tafenoquine, reducing memantine renal elimination.
What to do
Monitor for memantine adverse effects such as dizziness, confusion and agitation. Consider reducing the memantine dose if toxicity develops, particularly in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Memantine with Tafenoquine?
MediHelp rates the interaction as moderate. Memantine and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits renal OCT2 and MATE transporters in vitro, which may reduce the tubular secretion of memantine. This may raise memantine levels and increase dose-related adverse effects such as dizziness, confusion and agitation.
How serious is the interaction between Memantine and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for memantine adverse effects such as dizziness, confusion and agitation. Consider reducing the memantine dose if toxicity develops, particularly in renal impairment.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
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