Drug interactions
Memantine + Trilaciclib
Severity: Moderate
Memantine and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2 and MATE transporters, which may reduce the renal secretion of memantine and raise its levels. Higher memantine exposure may cause dizziness, confusion and other CNS effects, although the exposure to trilaciclib is short.
What this interaction means in plain words
Memantine and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine belongs to Central Nervous System; Trilaciclib belongs to Oncology.
Why it happens
Inhibition of renal OCT2, MATE1 and MATE2-K by trilaciclib, reducing memantine renal clearance.
What to do
Monitor for memantine adverse effects such as dizziness, confusion and agitation around the days of trilaciclib infusion. Consider a temporary memantine dose reduction if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Other interactions of Trilaciclib
Frequently asked questions
Can I take Memantine with Trilaciclib?
MediHelp rates the interaction as moderate. Memantine and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits OCT2 and MATE transporters, which may reduce the renal secretion of memantine and raise its levels. Higher memantine exposure may cause dizziness, confusion and other CNS effects, although the exposure to trilaciclib is short.
How serious is the interaction between Memantine and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for memantine adverse effects such as dizziness, confusion and agitation around the days of trilaciclib infusion. Consider a temporary memantine dose reduction if symptoms occur.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
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