Drug interactions
Memantine-donepezil + Moxifloxacin
Severity: Major
Memantine-donepezil and Moxifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin is among the fluoroquinolones with the greatest QT-prolonging effect. Together with donepezil, it can increase the risk of torsades de pointes, especially in older patients.
What this interaction means in plain words
Memantine-donepezil and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Memantine-donepezil belongs to Central Nervous System; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Choose a non-QT-prolonging antibiotic where feasible. If moxifloxacin is needed, check the ECG and electrolytes and monitor for palpitations or syncope.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Moxifloxacin?
MediHelp rates the interaction as major. Memantine-donepezil and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Moxifloxacin is among the fluoroquinolones with the greatest QT-prolonging effect. Together with donepezil, it can increase the risk of torsades de pointes, especially in older patients.
How serious is the interaction between Memantine-donepezil and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-QT-prolonging antibiotic where feasible. If moxifloxacin is needed, check the ECG and electrolytes and monitor for palpitations or syncope.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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