Drug interactions
Memantine-donepezil + Perphenazine
Severity: Moderate
Memantine-donepezil and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and perphenazine can prolong the QT interval, so combined use may increase arrhythmia risk. Perphenazine also has anticholinergic and dopamine-blocking effects that may reduce cognitive benefit and worsen parkinsonism.
What this interaction means in plain words
Memantine-donepezil and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus partial pharmacodynamic opposition at muscarinic receptors.
What to do
Obtain a baseline ECG and correct electrolytes. Monitor for arrhythmia symptoms, extrapyramidal effects and cognitive worsening.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Memantine-donepezil with Perphenazine?
MediHelp rates the interaction as moderate. Memantine-donepezil and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both donepezil and perphenazine can prolong the QT interval, so combined use may increase arrhythmia risk. Perphenazine also has anticholinergic and dopamine-blocking effects that may reduce cognitive benefit and worsen parkinsonism.
How serious is the interaction between Memantine-donepezil and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Monitor for arrhythmia symptoms, extrapyramidal effects and cognitive worsening.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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