Drug interactions
Memantine-donepezil + Ribociclib
Severity: Major
Memantine-donepezil and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib can prolong the QT interval, and donepezil has also been associated with QT prolongation and torsades de pointes. Ribociclib inhibits CYP3A4, which may modestly raise donepezil exposure and add to the arrhythmic risk.
What this interaction means in plain words
Memantine-donepezil and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Memantine-donepezil belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by ribociclib that may increase donepezil concentrations.
What to do
Avoid the combination where possible; if it is unavoidable, obtain a baseline ECG and monitor it along with electrolytes (potassium, magnesium). Correct electrolyte abnormalities and stop or switch therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Ribociclib?
MediHelp rates the interaction as major. Memantine-donepezil and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib can prolong the QT interval, and donepezil has also been associated with QT prolongation and torsades de pointes. Ribociclib inhibits CYP3A4, which may modestly raise donepezil exposure and add to the arrhythmic risk.
How serious is the interaction between Memantine-donepezil and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is unavoidable, obtain a baseline ECG and monitor it along with electrolytes (potassium, magnesium). Correct electrolyte abnormalities and stop or switch therapy if QTc becomes markedly prolonged.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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