Drug interactions
Memantine-donepezil + Solifenacin
Severity: Moderate
Memantine-donepezil and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin has a dose-related QT-prolonging effect and donepezil may also prolong the QT interval. Their pharmacologic actions are also opposed, since the anticholinergic solifenacin counteracts the cholinesterase inhibitor and may reduce the benefit of donepezil in dementia.
What this interaction means in plain words
Memantine-donepezil and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation and pharmacodynamic antagonism between anticholinergic and cholinesterase inhibitor effects.
What to do
Prefer a non-anticholinergic option for bladder symptoms where possible. If both are used, keep the solifenacin dose low and monitor cognition and the ECG in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Memantine-donepezil and Solifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Solifenacin
Frequently asked questions
Can I take Memantine-donepezil with Solifenacin?
MediHelp rates the interaction as moderate. Memantine-donepezil and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin has a dose-related QT-prolonging effect and donepezil may also prolong the QT interval. Their pharmacologic actions are also opposed, since the anticholinergic solifenacin counteracts the cholinesterase inhibitor and may reduce the benefit of donepezil in dementia.
How serious is the interaction between Memantine-donepezil and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-anticholinergic option for bladder symptoms where possible. If both are used, keep the solifenacin dose low and monitor cognition and the ECG in patients with additional QT risk factors.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
