Drug interactions
Memantine-donepezil + Tacrolimus
Severity: Moderate
Memantine-donepezil and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and tacrolimus have been associated with QT prolongation. Combined use may increase the chance of ventricular arrhythmia, especially in patients with electrolyte imbalance or bradycardia.
What this interaction means in plain words
Memantine-donepezil and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Check ECG at baseline and after changes in therapy, and keep potassium and magnesium within normal range. Monitor tacrolimus levels and watch for bradycardia or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Tacrolimus?
MediHelp rates the interaction as moderate. Memantine-donepezil and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both donepezil and tacrolimus have been associated with QT prolongation. Combined use may increase the chance of ventricular arrhythmia, especially in patients with electrolyte imbalance or bradycardia.
How serious is the interaction between Memantine-donepezil and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and after changes in therapy, and keep potassium and magnesium within normal range. Monitor tacrolimus levels and watch for bradycardia or syncope.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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