Drug interactions
Memantine-donepezil + Tipranavir
Severity: Minor
Memantine-donepezil and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, usually given with ritonavir, may inhibit enzymes that metabolize donepezil and raise its exposure. This could increase bradycardia and gastrointestinal effects.
What this interaction means in plain words
Memantine-donepezil and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Possible inhibition of CYP2D6 and CYP3A4 metabolism of donepezil, mainly via the ritonavir component.
What to do
Monitor heart rate and cholinergic adverse effects after starting the combination and reduce the donepezil dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Tipranavir?
MediHelp rates the interaction as minor. Memantine-donepezil and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tipranavir, usually given with ritonavir, may inhibit enzymes that metabolize donepezil and raise its exposure. This could increase bradycardia and gastrointestinal effects.
How serious is the interaction between Memantine-donepezil and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and cholinergic adverse effects after starting the combination and reduce the donepezil dose if needed.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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