Drug interactions
Memantine-donepezil + Voriconazole
Severity: Moderate
Memantine-donepezil and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole is a strong CYP3A4 inhibitor that can raise donepezil concentrations. Higher levels may increase cholinergic effects such as nausea, vomiting, bradycardia, and QT prolongation risk, as both drugs have been associated with QT effects.
What this interaction means in plain words
Memantine-donepezil and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated donepezil metabolism by voriconazole, with possible additive QT effects.
What to do
Monitor for bradycardia, GI intolerance, and QT prolongation, with an ECG in patients with cardiac risk factors. Correct potassium and magnesium and reduce the donepezil dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Voriconazole?
MediHelp rates the interaction as moderate. Memantine-donepezil and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole is a strong CYP3A4 inhibitor that can raise donepezil concentrations. Higher levels may increase cholinergic effects such as nausea, vomiting, bradycardia, and QT prolongation risk, as both drugs have been associated with QT effects.
How serious is the interaction between Memantine-donepezil and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bradycardia, GI intolerance, and QT prolongation, with an ECG in patients with cardiac risk factors. Correct potassium and magnesium and reduce the donepezil dose if adverse effects emerge.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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