Drug interactions
Meperidine + Metaxalone
Severity: Moderate
Meperidine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone is a sedating muscle relaxant that can add to opioid-induced drowsiness and psychomotor impairment. Metaxalone also has weak serotonergic activity, and serotonin syndrome has been reported with serotonergic drugs.
What this interaction means in plain words
Meperidine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with possible weak serotonergic contribution.
What to do
Monitor for sedation and, if feasible, use the lowest effective doses. Watch for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Metaxalone
Frequently asked questions
Can I take Meperidine with Metaxalone?
MediHelp rates the interaction as moderate. Meperidine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone is a sedating muscle relaxant that can add to opioid-induced drowsiness and psychomotor impairment. Metaxalone also has weak serotonergic activity, and serotonin syndrome has been reported with serotonergic drugs.
How serious is the interaction between Meperidine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and, if feasible, use the lowest effective doses. Watch for signs of serotonin toxicity.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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