Drug interactions
Meperidine + Naratriptan
Severity: Major
Meperidine and Naratriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and combining them may increase the risk of serotonin syndrome. Features include agitation, tremor, hyperthermia, clonus and autonomic instability.
What this interaction means in plain words
Meperidine and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meperidine belongs to Musculoskeletal; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects (5-HT1 agonism with opioid-mediated serotonin reuptake inhibition).
What to do
Consider an alternative analgesic to meperidine for patients using triptans. If used together, monitor for serotonin syndrome symptoms and counsel patients to seek care if they occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Meperidine with Naratriptan?
MediHelp rates the interaction as major. Meperidine and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have serotonergic activity, and combining them may increase the risk of serotonin syndrome. Features include agitation, tremor, hyperthermia, clonus and autonomic instability.
How serious is the interaction between Meperidine and Naratriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative analgesic to meperidine for patients using triptans. If used together, monitor for serotonin syndrome symptoms and counsel patients to seek care if they occur.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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