Drug interactions
Meperidine + Oliceridine
Severity: Major
Meperidine and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are opioid agonists, so using them together adds to the risk of sedation, respiratory depression, coma and death. Using two opioids simultaneously also complicates dose assessment.
What this interaction means in plain words
Meperidine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meperidine belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive mu-opioid receptor agonism leading to CNS and respiratory depression.
What to do
Avoid concurrent use where possible and use a single opioid titrated to effect. If both are needed, use minimal doses and monitor respiratory rate and sedation continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Meperidine with Oliceridine?
MediHelp rates the interaction as major. Meperidine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are opioid agonists, so using them together adds to the risk of sedation, respiratory depression, coma and death. Using two opioids simultaneously also complicates dose assessment.
How serious is the interaction between Meperidine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and use a single opioid titrated to effect. If both are needed, use minimal doses and monitor respiratory rate and sedation continuously.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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