Drug interactions
Meperidine + Quetiapine
Severity: Moderate
Meperidine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is markedly sedating and with meperidine produces additive drowsiness, hypotension and respiratory depression. Rare serotonin syndrome or neuroleptic malignant syndrome has been described with serotonergic opioids and antipsychotics.
What this interaction means in plain words
Meperidine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible serotonergic and dopamine-blocking pharmacodynamic effects.
What to do
Start with low doses, monitor sedation, blood pressure and respiratory status, and watch for hyperthermia, clonus or rigidity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Meperidine with Quetiapine?
MediHelp rates the interaction as moderate. Meperidine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is markedly sedating and with meperidine produces additive drowsiness, hypotension and respiratory depression. Rare serotonin syndrome or neuroleptic malignant syndrome has been described with serotonergic opioids and antipsychotics.
How serious is the interaction between Meperidine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses, monitor sedation, blood pressure and respiratory status, and watch for hyperthermia, clonus or rigidity.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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