Drug interactions
meperidine + tranylcypromine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Potentially fatal serotonin syndrome.
Mechanism of action
MAOI + serotonergic opioid.
Clinical management
Absolute avoidance.
Drug reference
References
- Meperidine – Label warnings with MAOIs — FDA Label
- MAOI meperidine reports — PubMed
Frequently asked questions
Can I take meperidine with tranylcypromine?
The interaction is rated: Contraindicated. Potentially fatal serotonin syndrome.
How serious is the interaction between meperidine and tranylcypromine?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between meperidine and tranylcypromine managed?
Absolute avoidance.
Why do meperidine and tranylcypromine interact?
MAOI + serotonergic opioid.
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