Drug interactions
Meperidine + Ziprasidone
Severity: Moderate
Meperidine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone and meperidine cause additive sedation and orthostatic hypotension. Ziprasidone prolongs QT, and rare serotonin syndrome or neuroleptic malignant syndrome has been described with serotonergic opioids and antipsychotics.
What this interaction means in plain words
Meperidine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible serotonergic and dopamine-blocking effects; ziprasidone independently prolongs QT.
What to do
Monitor sedation, blood pressure and serotonin toxicity signs, and check ECG and electrolytes in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Meperidine with Ziprasidone?
MediHelp rates the interaction as moderate. Meperidine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone and meperidine cause additive sedation and orthostatic hypotension. Ziprasidone prolongs QT, and rare serotonin syndrome or neuroleptic malignant syndrome has been described with serotonergic opioids and antipsychotics.
How serious is the interaction between Meperidine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and serotonin toxicity signs, and check ECG and electrolytes in patients with other QT risk factors.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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