Drug interactions
Meprobamate + Prochlorperazine
Severity: Moderate
Meprobamate and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative anxiolytic and prochlorperazine is also sedating, so together they can cause marked drowsiness, impaired coordination and hypotension. Risk is greater in older adults and with alcohol.
What this interaction means in plain words
Meprobamate and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergism.
What to do
Use the lowest effective doses and monitor for oversedation and falls. Avoid alcohol and advise caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Meprobamate with Prochlorperazine?
MediHelp rates the interaction as moderate. Meprobamate and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative anxiolytic and prochlorperazine is also sedating, so together they can cause marked drowsiness, impaired coordination and hypotension. Risk is greater in older adults and with alcohol.
How serious is the interaction between Meprobamate and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and falls. Avoid alcohol and advise caution with driving.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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