Drug interactions
Meprobamate + Propofol
Severity: Moderate
Meprobamate and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative anxiolytic, and combined with propofol it adds to sedation and respiratory depression. Patients may become more deeply sedated and hypotensive than expected from the propofol dose.
What this interaction means in plain words
Meprobamate and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with both drugs enhancing GABA-A receptor activity.
What to do
Reduce the propofol dose and titrate to the desired sedation level. Monitor respiration, oxygen saturation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Meprobamate with Propofol?
MediHelp rates the interaction as moderate. Meprobamate and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative anxiolytic, and combined with propofol it adds to sedation and respiratory depression. Patients may become more deeply sedated and hypotensive than expected from the propofol dose.
How serious is the interaction between Meprobamate and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the propofol dose and titrate to the desired sedation level. Monitor respiration, oxygen saturation and blood pressure.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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