Drug interactions
Mesalamine + Mycophenolate mofetil
Severity: Minor
Mesalamine and Mycophenolate mofetil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine is mainly acting locally in the gut with limited systemic exposure, so any renal competition with mycophenolic acid glucuronide is probably small. Mesalamine can occasionally cause nephrotoxicity or blood dyscrasias, which could add to mycophenolate effects.
What this interaction means in plain words
Mesalamine and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mesalamine belongs to Gastrointestinal Tract; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Possible minor competition for renal tubular secretion; mechanism not well established.
What to do
No routine adjustment is needed. Monitor renal function and blood counts periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Mesalamine
Frequently asked questions
Can I take Mesalamine with Mycophenolate mofetil?
MediHelp rates the interaction as minor. Mesalamine and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mesalamine is mainly acting locally in the gut with limited systemic exposure, so any renal competition with mycophenolic acid glucuronide is probably small. Mesalamine can occasionally cause nephrotoxicity or blood dyscrasias, which could add to mycophenolate effects.
How serious is the interaction between Mesalamine and Mycophenolate mofetil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and blood counts periodically.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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